1. Ex utero Intrapartum Treatment (EXIT) Procedure - StatPearls - NCBI
May 25, 2024 · The ex utero intrapartum treatment (EXIT) procedure represents a rare and high-risk intervention utilized to secure a fetal airway while maintaining placental ...
The ex utero intrapartum treatment (EXIT) procedure represents a rare and high-risk intervention utilized to secure a fetal airway while maintaining placental support before birth. Typically performed for fetuses with congenital airway obstructions or cardiopulmonary malformations, EXIT aims to establish a definitive airway before delivery. This procedure encompasses various techniques, including airway establishment, extracorporeal membrane oxygenation (ECMO), mass resection, and separation of conjoined twins. Due to its complexity, EXIT necessitates interprofessional teams and specialized tertiary care centers.
2. A Detailed Exploration of the Ex Utero Intrapartum Treatment Procedure ...
Ex utero intrapartum treatment (EXIT) is a specialized procedure developed to ensure a patent airway during the birth of fetuses that may face challenges in ...
The Ex Utero Intrapartum Treatment (EXIT) procedure has long been an invaluable tool in managing complex fetal conditions requiring airway interventions during the transition from intrauterine to extrauterine life. This technical note offers an in-depth examination of the EXIT procedure, emphasizing the refinements and innovations introduced at our center. The technique focuses on meticulous preoperative assessment and uses distinctive techniques and anesthetic methodologies. A multidisciplinary team assembles to plan the EXIT procedure, emphasizing patient communication and risk discussion. Our technique involves atraumatic access to the uterine cavity, achieved through the application of a uterine progressive distractor developed for this purpose. Following the use of this distractor, vascular clamps and a stapling device (Premium Poly Cs-57 Autosuture®, Medtronic) are employed. Our anesthetic approach employs general anesthesia with epidural catheter placement. Maternal operation involves low transverse laparotomy and intraoperative ultrasonography-guided hysterotomy. Fetal exposure includes gentle extraction or external version, ensuring airway access. After securing fetal airway access, umbilical cord clamping and maternal abdominal closure conclude the procedure. By revisiting the core principles of EXIT and incorporating center-specific advancements, we enhance our understanding and technical expertise. To our knowledge, this is the first time a detailed description of...
3. Ex-utero Intrapartum Treatment (EXIT) - Texas Children's Hospital
The EXIT procedure is a specialized fetal surgery operation that occurs at the time of birth for certain fetuses with rare conditions predicted to have ...
Ex-utero intrapartum treatment, or the “EXIT Procedure,” is a specialized fetal surgery operation that occurs at the time of birth for certain fetuses with rare conditions predicted to have problems immediately after birth. This procedure is performed similarly to other fetal surgical operations under general anesthesia. The mother’s abdomen and uterus are opened.
4. Ex-Utero Intrapartum Treatment (EXIT): indications and outcome in ...
Oct 7, 2020 · The “Ex-Utero Intrapartum Treatment” (EXIT) procedure allows to ensure fetal airway before completion of delivery and umbilical cord clamping ...
The “Ex-Utero Intrapartum Treatment” (EXIT) procedure allows to ensure fetal airway before completion of delivery and umbilical cord clamping while keeping uteroplacental circulation. Airway obstruction in fetal oropharyngeal and cervical ...
5. Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis
Mar 17, 2021 · Here we present highly effective platforms for the ex utero culture of post-implantation mouse embryos, which enable the appropriate development of embryos ...
The mammalian body plan is established shortly after the embryo implants into the maternal uterus, and our understanding of post-implantation developmental processes remains limited. Although pre- and peri-implantation mouse embryos are routinely cultured in vitro1,2, approaches for the robust culture of post-implantation embryos from egg cylinder stages until advanced organogenesis remain to be established. Here we present highly effective platforms for the ex utero culture of post-implantation mouse embryos, which enable the appropriate development of embryos from before gastrulation (embryonic day (E) 5.5) until the hindlimb formation stage (E11). Late gastrulating embryos (E7.5) are grown in three-dimensional rotating bottles, whereas extended culture from pre-gastrulation stages (E5.5 or E6.5) requires a combination of static and rotating bottle culture platforms. Histological, molecular and single-cell RNA sequencing analyses confirm that the ex utero cultured embryos recapitulate in utero development precisely. This culture system is amenable to the introduction of a variety of embryonic perturbations and micro-manipulations, the results of which can be followed ex utero for up to six days. The establishment of a system for robustly growing normal mouse embryos ex utero from pre-gastrulation to advanced organogenesis represents a valuable tool for investigating embryogenesis, as it eliminates the uterine barrier and allows researchers to mechanistically interrogate pos...
6. Ex utero synthetic embryos | Nature Methods
Sep 6, 2022 · A method to develop gastrulating embryoids from stem cells ex utero. In vitro cultured stem cells have been routinely used to develop embryonic ...
A method to develop gastrulating embryoids from stem cells ex utero.
7. EXIT Procedure | Children's Hospital Colorado
An Ex Utero Intrapartum Treatment (or EXIT procedure) is a highly specialized surgical procedure used to deliver high-risk babies. At the Colorado Fetal ...
An Ex Utero Intrapartum Treatment (or EXIT procedure) is a highly specialized surgical procedure used to deliver high-risk babies. At the Colorado Fetal Care Center, we offer state-of-the-art EXIT procedure facilities and expert care to provide the best care and outcomes for mom and baby.
8. The ex-utero intrapartum treatment (EXIT) strategy for fetal giant ...
Nov 2, 2022 · The ex-utero intrapartum treatment (EXIT) strategy for fetal giant sacrococcygeal teratoma with cardiac insufficiency: A case report and review ...
BackgroundAntenatally diagnosed sacrococcygeal teratoma has been associated with risks of perinatal complications and death, especially when the foetus has s...
9. Indications, Resource Allocation, and Outcomes Associated with Ex-Utero ...
Ex-utero intrapartum treatment (EXIT) is a complex surgical procedure used to deliver neonates with concerns for fetal airway obstruction or cardiopulmonary ...
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10. Artificial Womb Technology and the Choice to Gestate Ex Utero
Dec 18, 2019 · It is frequently claimed that artificial wombs (AWs) could alleviate the burdens placed exclusively on women in reproduction. In this article, I ...
Abstract. It is frequently claimed that artificial wombs (AWs) could alleviate the burdens placed exclusively on women in reproduction. In this article, I
